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活動報告

2018 Pubilcation

2018/01/21

Original Articles

    1. T. Akazawa, Y. Uchida, E. Miyauchi, M. Tachikawa, S. Ohtsuki, T. Terasaki: High Expression of UGT1A1/1A6 in Monkey Small Intestine: Comparison of Protein Expression Levels of Cytochromes P450, UDP-Glucuronosyltransferases, and Transporters in Small Intestine of Cynomolgus Monkey and Human.  Mol Pharm.  15:127-140 (2018)
    2. T. Kuno, M. Hirayama-Kurogi, S. Ito, S. Ohtsuki: Reduction in hepatic secondary bile acids caused by short-term antibiotic-induced dysbiosis decreases mouse serum glucose and triglyceride levels.  Sci Rep.  8:1253 (2018)
    3. K. Sasaki, M. Tachikawa, Y. Uchida, S. Hirano, F. Kadowaki, M. Watanabe, S. Ohtsuki, T. Terasaki: ATP-Binding Cassette Transporter A Subfamily 8 Is a Sinusoidal Efflux Transporter for Cholesterol and Taurocholate in Mouse and Human Liver.  Mol Pharm.  15:343-355 (2018)
    4. E. Miyauchi, T. Furuta, S. Ohtsuki, M. Tachikawa, Y. Uchida, H. Sabit, W. Obuchi, T. Baba, M. Watanabe, T. Terasaki, M. Nakada: Identification of blood biomarkers in glioblastoma by SWATH mass spectrometry and quantitative targeted absolute proteomics.  PLoS One.  13:e0193799 (2018)
    5. S. Nakamura, S.I. Muramatsu, N. Takino, M. Ito, E.F. Jimbo, K. Shimazaki, T. Onaka, S. Ohtsuki, T. Terasaki, T. Yamagata, H. Osaka: Gene therapy for Glut1-deficient mouse using an adeno-associated virus vector with the human intrinsic GLUT1 promoter.  J Gene Med.  20:e3013 (2018)
    6. Y. Yamasaki, K. Kobayashi, F. Okuya, N. Kajitani, K. Kazuki, S. Abe, S. Takehara, S. Ito, S. Ogata, T. Uemura, S. Ohtsuki, G. Minegishi, H. Akita, K. Chiba, M. Oshimura, Y. Kazuki: Characterization of P-Glycoprotein Humanized Mice Generated by Chromosome Engineering Technology: Its Utility for Prediction of Drug Distribution to the Brain in Humans.  Drug Metab Dispos.  46:1756-1766 (2018)
    7. M. Fukuda, T. Yoshizawa, M.F. Karim, S.U. Sobuz, W. Korogi, D. Kobayasi, H. Okanishi, M. Tasaki, K. Ono, T. Sawa, Y. Sato, M. Chirifu, T. Masuda, T. Nakamura, H. Tanoue, K. Nakashima, Y. Kobashigawa, H. Morioka, E. Bober, S. Ohtsuki, Y. Yamagata, Y. Ando, Y. Oike, N. Araki, S. Takeda, H. Mizuta, K. Yamagata: SIRT7 has a critical role in bone formation by regulating lysine acylation of SP7/Osterix.  Nat Commun.  9:2833 (2018)
    8. T. Yamauchi, T. Masuda, MC. Canver, M. Seiler, Y. Semba, M. Shboul, M. Al-Raqad, M. Maeda, VA. C. Schoonenberg, MA. Cole, C. M. Trevino, Y. Ishikawa, Q. Yao, M. Nakano, F. Arai, SH. Orkin, B. Reversade, S. Buonamici, L. Pinello, K. Akashi, DE. Bauer, T. Maeda: Genome-wide CRISPR-Cas9 screen identifies leukemia-specific dependence on a pre-mRNA metabolic pathway regulated by the DCPS decapping enzyme. Cancer Cell, DOI10.1016/j.ccell.2018.01.012 (2018)
    9. Y. Uchida, T. Sumiya, M. Tachikawa, T. Yamakawa, S. Murata, Y. Yagi, K. Sato, A. Stephan, K. Ito, S. Ohtsuki, P.O. Couraud, T. Suzuki, T. Terasaki: Involvement of Claudin-11 in Disruption of Blood-Brain, -Spinal Cord, and -Arachnoid Barriers in Multiple Sclerosis.  Mol Neurobiol.  (2018)
    10. S. Ito, Y. Fujino, S. Ogata, M. Hirayama-Kurogi, S. Ohtsuki: Involvement of an Orphan Transporter, SLC22A18, in Cell Growth and Drug Resistance of Human Breast Cancer MCF7 Cells.  J Pharm Sci.  107:3163-3170 (2018)
    11. H. Maruyama, T. Kimura, H. Liu, S. Ohtsuki, Y. Miyake, M. Isogai, F. Arai, A. Honda: Influenza virus replication raises the temperature of cells.  Virus Res.  257:94-101 (2018)

総説

    1. 米山敏広、大槻純男:早期膵がんの血中バイオマーカーへの新しいアプローチ、月刊ファインケミカル、47:39-45 (2018)
    2. 伊藤慎悟:生体関門輸送機能を基盤とした疾患メカニズムの解明と治療への展開 YAKUGAKU ZASSHI (Accepted)

解説

    1. 山口駿介、伊藤慎悟: Identification of cyclic peptides for facilitation of transcellular transport of phages across intestinal epithelium in vitro and in vivo、Drug Delivery System、日本DDS学会、33-1、 56 (2018)

総合論文

    1. 伊藤慎悟、大槻純男:SWATH法を用いた網羅的定量プロテオーム解析による薬物動態研究の新展開 Proteome Letters (Accepted)

トピックス

    1. 伊藤慎悟:腸内フローラが薬の効果と副作用に与える影響、バイオサイエンスとインダストリー(B&I)、76 (5) (2018)

著書

    1. 久野琢矢、大槻純男:第3章、第9節 腸内細菌叢の変化が薬効に与える影響、「腸内細菌叢を標的にしたい薬品と保健機能食品の開発」、技術情報協会、164-70 (2018)