Original Articles

1. S. Ito, W. Lee, J.E. Park, M. Yasunaga, A. Mori, S. Ohtsuki, Y. Sugiyama: Transient, Tunable Expression of NTCP and BSEP in MDCKII Cells for Kinetic Delineation of the Rate-Determining Process and Inhibitory Effects of Rifampicin in Hepatobiliary Transport of Taurocholate. J Pharm Sci. 110:365-375 (2021)
2. R. Yokoyama, T. Taharabaru, T. Nishida, Y. Ohno, Y. Maeda, M. Sato, K. Ishikura, K. Yanagihara, H. Takagi, T. Nakamura, S. Ito, S. Ohtsuki, H. Arima, R. Onodera, T. Higashi, K. Motoyama: Lactose-appended beta-cyclodextrin as an effective nanocarrier for brain delivery. J Control Release. 328:722-735 (2020)
3. H. Terai, J. Hamamoto, T. Manabe, K. Emoto, T. Masuda, S. Kuronuma, K. Kobayashi, K. Masuzawa, S. Ikemura, S. Nakayama, I. Kawada, Y. Suzuki, O. Takeuchi, Y. Suzuki, S. Ohtsuki, H. Yasuda, K. Soejima, K. Fukunaga: SHOC2 is a critical modulator of the sensitivity to EGFR-TKI in non-small cell lung cancer cells. Cancer Research (2020)
4. R. Yagi, T. Masuda, S. Ogata, A. Mori, S. Ito, S. Ohtsuki: Proteomic evaluation of plasma membrane fraction prepared from mouse liver and kidney using a bead homogenizer: Enrichment of drug-related transporter proteins. Mol Pharm. 17: 4101-13 (2020)
5. T. Furuta, Y. Sugita, S. Komaki, K. Ohshima, M. Morioka, Y. Uchida, M. Tachikawa, S. Ohtsuki, T. Terasaki, M. Nakada: The Multipotential of Leucine-Rich alpha-2 Glycoprotein 1 as a Clinicopathological Biomarker of Glioblastoma. J Neuropathol Exp Neurol. 79:873-879 (2020)
6. K. Matsumoto, K. Kinoshita, M. Hijioka, Y. Kurauchi, A. Hisatsune, T. Seki, T. Masuda, S. Ohtsuki, H. Katsuki: Nicotine promotes angiogenesis in mouse brain after intracerebral hemorrhage. Neurosci Res. (2020)
7. T. Kohata, S. Ito, T. Masuda, T. Furuta, M. Nakada, S. Ohtsuki: Laminin Subunit Alpha-4 and Osteopontin Are Glioblastoma-Selective Secreted Proteins That Are Increased in the Cerebrospinal Fluid of Glioblastoma Patients. J Proteome Res. 19:3542-3553 (2020)
8. S. Ogata, S. Ito, T. Masuda, S. Ohtsuki: Efficient isolation of brain capillary from a single frozen mouse brain for protein expression analysis. J Cereb Blood Flow Metab. 271678X20941449 (2020)
9. S. Ito, M. Oishi, S. Ogata, T. Uemura, P.O. Couraud, T. Masuda, S. Ohtsuki: Identification of Cell-Surface Proteins Endocytosed by Human Brain Microvascular Endothelial Cells In Vitro. Pharmaceutics. 12 (2020)
10. M. Tokuno, K. Taguchi, H. Sakai, S. Ohtsuki, K. Yamasaki, M. Otagiri: Evaluation of cytochrome P450-based drug metabolism in hemorrhagic shock rats that were transfused with native and an artificial red blood cell preparation, Hemoglobin-vesicles. Drug Metab Pharmacokinet. 35: 417-24 (2020)
11. M. Tokuno, K. Taguchi, H. Sakai, S. Ohtsuki, K. Yamasaki, M. Otagiri: Assessing cytochrome P450-based drug-drug interactions with hemoglobin-vesicles, an artificial red blood cell preparation, in healthy rats. Drug Metab Pharmacokinet. 35: 425-31 (2020)
12. M. Nambu, S. Nishiumi, T. Kobayashi, T. Masuda, S. Ito, M. Yoshida, S. Ohtsuki: Effects of differences in pre-analytical processing on blood protein profiles determined with SWATH-MS. J Proteomics. 223:103824 (2020)
13. Y. Yamashiro, B.Q. Thang, K. Ramirez, S.J. Shin, T. Kohata, S. Ohata, T.A.V. Nguyen, S. Ohtsuki, K. Nagayama, H. Yanagisawa: Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling. Proc Natl Acad Sci U S A. 117:9896-9905 (2020)
14. J. Zhang, T. Furuta, H. Sabit, S. Tamai, S. Jiapaer, Y. Dong, M. Kinoshita, Y. Uchida, S. Ohtsuki, T. Terasaki, S. Zhao, M. Nakada: Gelsolin inhibits malignant phenotype of glioblastoma and is regulated by miR-654-5p and miR-450b-5p. Cancer Sci. 111:2413-2422 (2020)
15. C. Liu, Y. Kobashigawa, S. Yamauchi, N. Fukuda, T. Sato, T. Masuda, S. Ohtsuki, H. Morioka: Convenient method of producing cyclic single-chain Fv antibodies by split-intein-mediated protein ligation and chaperone co-expression. J Biochem.  (2020)
16. S. Yamaguchi, S. Ito, T. Masuda, P.O. Couraud, S. Ohtsuki: Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo. J Control Release. 321:744-755 (2020)
17. T. Uemura, S. Ito, T. Masuda, H. Shimbo, T. Goto, H. Osaka, T. Wada, P.O. Couraud, S. Ohtsuki: Cyclocreatine Transport by SLC6A8, the Creatine Transporter, in HEK293 Cells, a Human Blood-Brain Barrier Model Cell, and CCDSs Patient-Derived Fibroblasts. Pharm Res. 37:61 (2020)
18. M. Tachikawa, Y. Kaneko, S. Ohtsuki, Y. Uchida, M. Watanabe, H. Ohtsuka, T. Terasaki: Targeted Proteomics-Based Quantitative Protein Atlas of Pannexin and Connexin Subtypes in Mouse and Human Tissues and Cancer Cell Lines.  J Pharm Sci. 109:1161-1168 (2020)
19. T. Masuda, N. Sugiyama, M. Tomita, S. Ohtsuki, Y. Ishihama: Mass Spectrometry-Compatible Subcellular Fractionation for Proteomics.  J Proteome Res. 19:75-84 (2020)

Review Articles

1. T. Masuda, A. Mori, S. Ito, S. Ohtsuki: Quantitative and targeted proteomics-based identification and validation of drug efficacy biomarkers. Drug Metabolism and Pharmacokinetics (2020)