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活動報告

論文業績

2011

Original Articles
  1. S. Akanuma, Y. Uchida, S. Ohtsuki, M. Tachikawa, T. Terasaki, K. Hosoya:Attenuation of prostaglandin E2 elimination across the mouse blood-brain barrier in lipopolysaccharide-induced inflammation and additive inhibitory effect of cefmetazole.Fluids Barriers CNS.8:24 (2011)
  2. Y. Uchida, S. Ohtsuki, Y. Katsukura, C. Ikeda, T. Suzuki, J. Kamiie, T. Terasaki:Quantitative targeted absolute proteomics of human blood-brain barrier transporters and receptors.J Neurochem.117:333-45 (2011)
  3. M. Fujiyoshi, M. Tachikawa, S. Ohtsuki, S. Ito, Y. Uchida, S. Akanuma, J. Kamiie, T. Hashimoto, K. Hosoya, T. Iwatsubo, T. Terasaki:Amyloid-beta peptide(1-40) elimination from cerebrospinal fluid involves low-density lipoprotein receptor-related protein 1 at the blood-cerebrospinal fluid barrier.J Neurochem.118:407-15 (2011)
  4. R. Shawahna, Y. Uchida, X. Decleves, S. Ohtsuki, S. Yousif, S. Dauchy, A. Jacob, F. Chassoux, C. Daumas-Duport, P.O. Couraud, T. Terasaki, J.M. Scherrmann:Transcriptomic and Quantitative Proteomic Analysis of Transporters and Drug Metabolizing Enzymes in Freshly Isolated Human Brain Microvessels.Mol Pharm.8:1332-1341 (2011)
  5. Y. Uchida, S. Ohtsuki, J. Kamiie, T. Terasaki:Blood-Brain Barrier (BBB) Pharmacoproteomics (PPx): Reconstruction of In Vivo Brain Distribution of 11 P-glycoprotein Substrates based on the BBB Transporter Protein Concentration, In Vitro Intrinsic Transport Activity, and Unbound Fraction in Plasma and Brain in Mice.J Pharmacol Exp Ther.339:579-88 (2011)
  6. S. Akanuma, Y. Uchida, S. Ohtsuki, J. Kamiie, M. Tachikawa, T. Terasaki, K. Hosoya:Molecular-weight-dependent, Anionic-substrate-preferential Transport of beta-Lactam Antibiotics via Multidrug Resistance-associated Protein 4.Drug Metab Pharmacokinet.26:602-11 (2011)
  7. S. Ito, S. Ohtsuki, Y. Katsukura, M. Funaki, Y. Koitabashi, A. Sugino, S. Murata, T. Terasaki:Atrial natriuretic peptide is eliminated from the brain by natriuretic peptide receptor-C-mediated brain-to-blood efflux transport at the blood-brain barrier.J Cereb Blood Flow Metab.31:457-66 (2011)
  8. H. Kawakami, S. Ohtsuki, J. Kamiie, T. Suzuki, T. Abe, T. Terasaki:Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.J Pharm Sci.100:341-52 (2011)
  9. F. Shimizu, Y. Sano, M.A. Abe, T. Maeda, S. Ohtsuki, T. Terasaki, T. Kanda:Peripheral nerve pericytes modify the blood-nerve barrier function and tight junctional molecules through the secretion of various soluble factors.J Cell Physiol.226:255-66 (2011)
  10. S. Ito, S. Ohtsuki, Y. Nezu, Y. Koitabashi, S. Murata, T. Terasaki:1a,25-Dihydroxyvitamin D3 enhances cerebral clearance of human amyloid-b peptide(1-40) from mouse brain across the blood-brain barrier.Fluids Barriers CNS.8:20 (2011)
  11. K. Ito, Y. Uchida, S. Ohtsuki, S. Aizawa, H. Kawakami, Y. Katsukura, J. Kamiie, T. Terasaki:Quantitative membrane protein expression at the blood-brain barrier of adult and younger cynomolgus monkeys.J Pharm Sci.100:3939-50 (2011)
  12. T. Okura, S. Kato, Y. Takano, T. Sato, A. Yamashita, R. Morimoto, S. Ohtsuki, T. Terasaki, Y. Deguchi:Functional characterization of rat plasma membrane monoamine transporter in the blood-brain and blood-cerebrospinal fluid barriers.J Pharm Sci.100:3924-38 (2011)
  13. A. Sakamoto, T. Matsumaru, N. Ishiguro, O. Schaefer, S. Ohtsuki, T. Inoue, H. Kawakami, T. Terasaki:Reliability and robustness of simultaneous absolute quantification of drug transporters, cytochrome P450 enzymes, and Udp-glucuronosyltransferases in human liver tissue by multiplexed MRM/selected reaction monitoring mode tandem mass spectrometry with nano-liquid chromatography.J Pharm Sci.100:4037-43 (2011)
  14. N.Y. Lee, Y. Sai, E. Nakashima, S. Ohtsuki, Y.S. Kang:6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs.J Pharm Sci.100:3773-82 (2011)
Review Articles
  1. S. Ohtsuki, Y. Uchida, Y. Kubo, T. Terasaki:Quantitative targeted absolute proteomics-based ADME research as a new path to drug discovery and development: Methodology, advantages, strategy, and prospects.J Pharm Sci.100:3547-59 (2011)
総説
  1. 内田康雄、大槻純男、寺崎哲也：Pharmacoproteomics (PPx)に基づく血液脳関門輸送機能の解明、遺伝子医学MOOK19、148-154 (2011)
  2. 大槻純男：脳関門輸送機構を利用した神経変性疾患に対する新たな治療戦略の構築、インテリジェントコスモス学術振興財団紀要、15:13-16 (2011)
  3. 元井冬彦、川口桂、大峰健、大槻純男、大塚英郎、力山敏樹、片寄友、江川新一、寺崎哲也、海野倫明：膵がん個別化医療-分子生物学形跡を中心に-、外科、73:1073-1078 (2011)
  4. 立川正憲、内田康雄、大槻純男、寺崎哲也：定量的絶対標的プロテオミクスに基づくヒト血液脳関門におけるトランスポーターの発現と生理機能、脳21、14:42-48 (2011)
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